Heterochromia Iridis in congenital Horner's syndrome.

A 35-year-old man, followed due to idiopathic generalized epilepsy, presented heterochromia (eyes of two different colours), together with anisocoria (condition in which the left pupil is smaller than the right pupil). The anisocoria became more pronounced in the dark. The patient reported that his eyes had been of different colours ever since he could remember. A diagnosis of idiopathic congenital left-sided Horner’s syndrome was made. Heterochromia may be found in different conditions, including Sturge-Weber, Waardenburg and Parry-Romberg syndromes, ocular trauma, Fuchs’ heterochromic iridocyclitis, and congenital and acquired Horner’s syndrome. A unilateral lack of sympathetic stimulation during childhood interferes with the melanin pigmentation of the melanocytes in the iris, resulting in heterochromia [1, 2] . Received: January 5, 2010 Accepted: January 6, 2010 Published online: April 7, 2010